STAT3 and neoplasm: However, 6-shogaol has better biological activity against tumor cells and in murine models, which can be attributed to its main conjugated metabolite, cysteinyl-6-shogaol, which is a product of its pharmacokinetics and that enhances the ability of 6-shogaol to halt cell cycle progression, induce apoptosis, and inhibit cell growth through the modulation of cellular signaling of NF-kB and STAT3 [20].