BAG1 and colorectal carcinoma: Finally, a G-quadruplex secondary structure located at the 5′ end of the 5′UTR of the BAG-1 mRNA, specifically at positions 6 to 35 (29) (Figure 1A and C), was previously probed in vitro and shown to repress the expression of a luciferase reporter gene in three CRC cell lines (30).