CXCR1 and neoplasm: The signaling pathways activated by IL-8 (PI3K and phospholipase C) are stimulated through the interaction of the cytokine with CXCR1/2 that are expressed by neutrophils, monocytes, endothelial cells, astrocytes, microglia, and different types of tumor cells (Thomson, 1998; Hillyer et al., 2003; Ha et al., 2017).