VEGFA and neoplasm: These tumor-associated macrophages (TAMs) provide an immunosuppressive microenvironment (Zheng et al., 2009; Gutierrez-Gonzalez et al., 2016), participate in angiogenesis through the release of vascular endothelial growth factors and protect tumor cells against paclitaxel chemotherapy for solid tumors (Shree et al., 2011), or melphalan-induced apoptosis in the case of multiple myeloma (Beyar-Katz et al., 2016).