IL6 and ovarian cancer: With regards to the M1 markers (Mantovani et al., 2004), our data suggest a slight upregulation of IL-1β, IL-6, and TLR-2 expression in the presence of MSCs and reparixin (Figure 6D), despite the fact that gene expression profiles reveal usually an M1/M2 mixed-polarization phenotype in ovarian cancer (Reinartz et al., 2014; Zheng et al., 2017).