These effects on BP were accompanied by reduction of systemic pro-hypertensive cytokine levels ([IFN-γ, IL-6, IL-17A, and TNF-α), as well as activated (CD38+) and immunosenescent dysregulated CD57+/CD28null CD8+ T cells, that were previously linked to hypertension.34 The gene discussed is TNF; the disease is hypertensive disorder.