Thus, we used the SDT fatty rat model to investigate the effects of osteoporosis drugs with different mechanisms of action, including the anabolic agent PTH [teriparatide (TPTD)] and the antiresorptive agents calcitonin [elcatonin (ECT)] and bisphosphonate [risedronate (RIS)], on bone geometry, BMD, mechanical strength, microstructure, and metabolism in trabecular and cortical bone. This evidence concerns the gene PTH and osteoporosis.