From a pathological perspective, Alzheimer’s disease is characterized by extensive accumulation of extracellular amyloid-β soluble peptides and plaques, and intracellular neurofibrillary tau tangles, together with gliosis, neuronal dystrophy and loss, and vascular alteration (Sala Frigerio and De Strooper, 2016). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.