Although the blockade of microglial proliferation seems to have an impact on tau aggregation, similar strategies have failed to modify the amyloid-β deposition in APP/PS1 (Olmos-Alonso et al., 2016), 3xTg-AD (Dagher et al., 2015) and 5xTg-AD (Spangenberg et al., 2016; Sosna et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.