APP and Alzheimer disease: Either blockade of proliferation or partial ablation of microglia in APP/PS1 (Olmos-Alonso et al., 2016), 3xTg-AD (Dagher et al., 2015) and 5xTgAD (Spangenberg et al., 2016; Sosna et al., 2018) models resulted in prevention of synaptic pathology and attenuation of cognitive deficits.