CACUL1 and colorectal carcinoma: In addition to the already reported CAC1 role in cell cycle regulation in CRC cell line HCT-8 and gastric cell line AGS, several recent studies have shown that CAC1 acts as a corepressor of retinoic acid receptor-α (RARα) [15], and is involved in ERα regulation by binding to it and repressing its transcriptional activity [16].