Also, Anti-EGFR leads to 0.77±0.128 and 0.86±0.157 fold tumor growth at 3 and 5 weeks after castration relative to castration only (Fig 6N), which are close to the experimental observation of in vivo effects of EGFR inhibitors in 22RV1 xenografts mice model [28]. Here, EGFR is linked to neoplasm.