At the tissue level, intracellular signaling pathways were triggered by the secreted cytokines, such as WNT5A, TRAIL, CSF1, EGF, IL-2, VEGF, and IL10, locally via the interfaces of cell agents, and result in the changes in the cells’ fate and behaviors, which in turn modulate the tumor mE for cell growth and response to treatment. Here, VEGFA is linked to neoplasm.