AR and posterior cortical atrophy: Taking above studies together, we hypothesize that 1) following ADT, the reactivation of AR signaling in PC cells and the altered immune mE contribute to the development of CRPC; 2) the communication between immune cells and PCs results in immune suppression and PCa progression; 3) targeting the immune-PC pathways mediated by cytokines after ADT may prevent CRPC development.