NKX2-1 and lung adenocarcinoma: For example, NKX2‐1 is another master regulator of pulmonary differentiation downregulated in poorly differentiated lung adenocarcinoma, which interacts with FOXA1/FOXA2 in human cell lines, regulates global Foxa1/Foxa2 binding in murine adenocarcinoma and cooperates to inhibit metastasis.71, 73 Interestingly, our master regulator analysis also retrieved NKX2‐1 as a common MR of lung adenocarcinoma, sharing several targets with FOXA2 in TN1.