HOXA4 (Homeobox A4) belongs to the Homeobox gene family of transcription factors associated with cell differentiation and embryonic development control.48HOXA4 regulation seems to associate with lung cancer cell proliferation, migration, and invasion in vitro and in vivo, besides poor prognosis in patients.49, 50 We identified that the inferred regulatory unit of HOXA4 is enriched with differentially expressed genes and its activity was suppressed in tumor tissues compared to control tissues. Here, HOXA4 is linked to lung carcinoma.