DACH1 is a key member of the retinal determination gene network, a group which affects cell cycle regulation and cancer cell growth, EMT, invasion, and migration in a context‐specific manner.57 Its reduced expression is observed in several types of cancer, mostly associated with poor prognosis.58 Our results also point that these TFs' inferred activity is repressed in lung adenocarcinoma, similarly to previous lung cancer studies.59, 60, 61 Interestingly, DACH1 activity did not show a consistently remarkable association with risk in our survival evaluation. Here, DACH1 is linked to cancer.