Then, a putative binding site for miR‐106b‐5p was identified in the 3'‐UTR of RUNX3, and luciferase reporter assay was carried out in HCC cells co‐transfected with miR‐106b‐5p mimics or miR‐NC and RUNX3‐WT‐3′‐UTR or RUNX3‐MUT‐3′‐UTR (Figure 5A). This evidence concerns the gene RUNX3 and hepatocellular carcinoma.