ATG12 and Alzheimer disease: It were found to be relieved that the lesions of the AD when the miR‐124 was injected into the bilateral dentate gyrus of the hippocampus of the AD model mice; further studies showed that miR‐124 indirectly inhibited abnormal autophagy via BACE1‐regulated autophagy pathway, thus exerting its neuroprotective effects.110 MiR‐214‐3p was a negative regulator of autophagy in hippocampal neuron by directly and negatively targeting the 3 ́‐untranslated region of Atg12, and it was downregulated in AD patients and AD model mice.