TFEB and Alzheimer disease: Similarly, the loss of PS1 may lead to severe autophagy impairment in neuronal stem cells (NSCs), aggravating AD lesions, and its underlying mechanism was that deletion of PS1 inhibited the ERK/CREB signaling pathway and activated GSK3 to downregulate the TFEB expression in NSCs.124 Besides, recent studies have reported that PS2 mutation impaired autophagy by causing a block in the degradative flux at the level of the autophagosome‐lysosome fusion step.