Autophagy is constitutively active and efficient in normal neurons, while the autophagy dysfunction is observed in AD.8 The regulation of autophagy involves in complex signaling transduction pathways, which can be mainly divided into two aspects: the mTOR‐dependent manner and mTOR‐independent manner; however, both the two regulating pathways were found to be abnormal in AD.9, 10 There may be a bi‐directional relationship between autophagy dysfunction and AD pathology: Aβ and Tau, which constitutes a vicious cycle to worsen the AD. This evidence concerns the gene MAPT and Alzheimer disease.