Currently, it is more likely that neuronal toxic proteins such as Aβ aggregation, Tau hyperphosphorylation, and abnormal or insufficient autophagy are the causes of AD.7, 85, 130 The complex autophagy process signal transduction includes many pathways, so the discovery and design of drugs regulating these pathways may be an important method for the treatment and prevention of AD. The gene discussed is MAPT; the disease is Alzheimer disease.