SIRT1 and Alzheimer disease: After downregulating miR‐34a expression, autophagy can be activated via the SIRT1/mTOR pathway.114 Chronic cerebral hypoperfusion (CCH) is one of the high‐risk factors for AD, and miR‐96‐mediated mTOR‐dependent autophagy has been shown to be involved in its pathogenesis.115 Because, the miR‐96 levels were significantly elevated, and the amount of LC3 and the level of Beclin‐1 positive autophagosomes increased in the CCH model mice, while mTOR levels decreased.