APP and Alzheimer disease: The mutation of APP can also cause abnormal autophagy and worsen AD progression.42 The expression of mutant APP was reported to be associated with impaired mitochondrial energy metabolism in AD neurons,43 and it has been found that the hippocampal mutant APP caused the mitophagy dysfunction in mAPP hippocampal cells and 12‐month‐old APP transgenic mice.42, 44 At the same time, autophagy failure can activate γ‐secretase complex to promote APP production and cause Aβ production.45 This was a malignant loop that can exacerbate AD.