In recent years, it has confirmed that Beclin‐1 was impaired in AD, and the overall expression of Beclin‐1 was downregulated in AD’s brain.116, 117 A growing body of evidence suggested that Beclin‐1 played a significant role in autophagy, and the identification of Beclin‐1 protein modification has also been shown that Beclin‐1 involved in autophagy regulation, but the specific mechanism is unclear.118 In addition, Beclin‐1 can behave as Aβ regulator through autophagy. This evidence concerns the gene BECN1 and Alzheimer disease.