The accumulation of ROS in neuronal cells was regarded as another characteristic of AD progression.33 In the context of ROS oxidation, proteins can be polymerized, as a result of forming the protein aggravates.34 ROS was able to induce autophagy via autophagy‐related gene 4 (Atg4) and blocked the Atg4 expression can significantly downregulate the levels of Beclin‐1 and light chain 3‐II (LC3‐II) protein expression (two proteins of autophagy markers).27 (d) The TyrRS/PARP1/SIRT1 pathway. Here, SIRT1 is linked to Alzheimer disease.