MAPT and Alzheimer disease: On the one hand, it has confirmed that induction of autophagy can promote the clearance and degradation of AD pathology in the brain of AD patients and animal model.11 On the other hand, the autophagy goes aberrant accompanied AD progression,12 and both the increased Aβ and Tau expression lead to defective autophagy and mitophagy in AD.13 In return, it has reported that the autophagy‐lysosomal pathway also plays a role in secretion of Aβ and Tau,14, 15, 16 which further deteriorate autophagy function and accelerate AD development.