BACE1 and Alzheimer disease: The β‐Site amyloid precursor protein (APP) was a type I trans‐membrane protein, which sequentially cleaved by β‐secretase (BACE1) and γ‐secretase to produce Aβ.36 Increased BACE1 and γ‐secretase activities were described to promote the APP converted to Aβ, thus accelerating AD progression.37 In the processing of APP, the autophagy played a crucial role.