miR‐21a‐5p has been reported previously as overexpressed in ovarian tumors by multiple studies20, 24 and is being tested for potential use as a circulating tumor biomarker for ovarian cancer detection.25 In addition, a recent study has found that miR‐21a‐5p plays a role in epithelial to mesenchymal transition, demonstrating its oncogenic potential.21 Therefore, the effects of PTEN knockdown in tumorigenesis may be also mediated by this miRNA. This evidence concerns the gene PTEN and ovarian neoplasm.