In addition, TUNEL staining and Western blot analysis for Bcl‐2/Bim showed that TIC10 significantly enhanced the apoptosis of the CMs (Figure 5E,G), indicating that the FOXO3A as one of the target of the GSK‐3β could regulate endotoxemia cardiac dysfunction which might attribute to its pro‐apoptotic effect on the CMs. This evidence concerns the gene FOXO3 and serum lipopolysaccharide activity.