To confirm the FOXO3A function in the LPS‐induced sepsis in CMs, knock‐down assay showed the expression level of FOXO3A was significantly decreased in the CMs transfected with the siRNA targeting FOXO3A for 48 hours (Figure 6A,B), in which the LPS‐induced up‐regulation of IL‐6, IL‐1β, TNF‐α and iNOs was suppressed (Figure 6C). The gene discussed is TNF; the disease is Sepsis.