In comparing frequency of somatic alterations in HAI (n = 370) vs non‐HAI (n = 317) CLM patients, KRAS and BRAF mutations were more frequent in the non‐HAI cohort (q = 0.001 for KRAS; q = 0.05 for BRAF; Figure S2), likely representing patient selection for liver‐limited disease in the HAI cohort.22 In contrast, no statistically significant differences in somatic alteration frequencies were observed for any individual gene across the Adj, Met‐EHD(‐), and Met‐EHD(+) subgroups (Figure 2A). Here, BRAF is linked to nosocomial infection.