In our study, we investigated lncRNAs that were differentially expressed during liver cancer progression and cellular senescence by integrating existing data and focused our research on lncRNA miat. We found that, sh-miat could induce cellular senescence and delay HCC progression, which indicates that miat may play a role as a bridge in cell senescence and HCC progression. The gene discussed is MIAT; the disease is hepatocellular carcinoma.