CXCL8 and hepatocellular carcinoma: Thus, we next investigated the change of SASP HCC cellular senescence induced by miat. We detected the significant induction of major pro-inflammatory cytokines, such as tnf-α, il-1α, il-1β, il-6, and il-8 in miat silenced HepG2 cell lines and found that miat silencing promotes the secretion of SASP in HCC cell lines (Figure 6Q and Supplementary Figure 8O).