Here, we found that knockdown of miat could inhibit the expression of sirt1 (Figure 6A and Supplementary Figure 8A), whereas these effects were significantly strengthened with miR-22-3p overexpression, but reversed after miR-22-3p KD in both two HCC cell lines (Figure 6B and Supplementary Figure 8B). The gene discussed is MIAT; the disease is hepatocellular carcinoma.