The results showed that miat knockdown significantly enhanced the mRNA and protein expression of p53, p21, p16 and pRb (Figure 6G, 6H and Supplementary Figure 8F, 8G), and these effects were significantly strengthened with miR-22-3p overexpression, but reversed after inhibition of miR-22-3p in HCC cell lines (Figure 6I, 6J and Supplementary Figure 8H, 8I). The gene discussed is TP53; the disease is hepatocellular carcinoma.