Two of eight (25%) patients with limited cutaneous systemic sclerosis, 10 of 31 (32.3%) patients with diffuse cutaneous systemic sclerosis, 9 of 22 (40.9%) patients with Sjoegren's syndrome (SjS), 1 of 3 (33.33%) patients with mixed connective tissue disease, 4 of 33 (12.1%) patients with dermatomyositis or polymyositis, 6 of 15 (40.0%) patients with antiphospholipid syndrome, and 2 of 11 (18.2%) patients with undifferentiated connective tissue disease were positive for progranulin antibodies (Figure 1). Here, GRN is linked to mixed connective tissue disease.