Moreover, PGRN is nowadays considered to be a key player in autoimmune diseases.12 PGRN is a strong anti‐inflammatory mediator acting through the inhibition of TNFR1 and TNFR2.13 The peptide chain consisting of granulin fragments F, A, and C with their linker regions was identified as the relevant ligand for TNFR1 and TNFR2 with an inhibitory effect. This evidence concerns the gene TNFRSF1B and autoimmune disease.