PDE3A and type 2 diabetes mellitus: Also, only a few genetic variants relate to both adiponectin levels [33] and height, e.g. in LYPLAL1 and PDE3A. Still, it is conceivable that several overlapping and complex biologic pathways on the one hand influence height and on the other hand influence the risk of type 2 diabetes through an effect on lipid metabolism and function of adipose tissue (electronic supplementary material [ESM] Fig. 1).