GATA2 and Familial prostate cancer: In prostate cancer, GATA2 facilitates androgen-responsive gene expression by three distinct modes of action: enhancing expression of AR itself, facilitating AR-enhancer binding by establishing an accessible local chromatin environment, and enhancing AR target gene expression through involvement in the formation and maintenance of regulatory chromatin loops between AR-bound distal enhancers and AR target gene promoters (21,46).