GATA2 and prostate cancer: While a previous study shows that 20 μM K7174 decreases the GATA2 protein level and thus impairs GATA2-mediated transcription and prostate cancer growth (41), we found that 10 μM K7174 significantly decreases GATA2 chromatin binding and enzalutamide-induced transcription without affecting GATA2 protein levels (Figure 4).