Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is a rare, inherited disorder caused by defects in the TYMP gene that results in dysfunctional thymidine phosphorylase (TP). TP participates in nucleotide metabolism and dysfunction leads to an accumulation of its nucleoside substrates that disrupts mitochondrial DNA processing [1-2]. This evidence concerns the gene TYMP and mitochondrial neurogastrointestinal encephalomyopathy.