CDS2 and neoplasm: After retro-orbital or intravenous injection of cell-permeable CDS2-specfiic vivo-morpholinos (chemical-modified morpholino with cell penetrating capability) into mice with implanted B16 tumors, they worked efficiently to trigger vessel regression and block tumor progression as that occurred in Cds2 endothelium-specific knockout mice (Supplementary information, Fig. S8i–k).