Mutations of the SCN2A gene, which encodes the voltage-gated sodium channel Nav1.2, have been associated to a wide spectrum of epileptic disorders ranging from mild forms, as benign familial neonatal-infantile seizures (BFNIS), to very severe ones, as early-infantile epileptic encephalopathies, Ohtahara syndrome or West syndrome1–6. This evidence concerns the gene SCN2A and Epileptic encephalopathy.