SCN2A and Anxiety: However, in contrast to young Scn2a+/− mice, no significant genotype effect was detected on the percentage of time spent in the center area of the open-field (unpaired Student’s t-test, t(29) = 1.36, p = 0.1846) or in the open arms of the plus maze (unpaired Student’s t-test, t(29) = 0.13, p = 0.9001), indicating that adult heterozygous mice do not display lower anxiety (Fig. 4F–H; Table 1).