We recently showed that the Epstein-Barr virus (EBV)-encoded oncogenic protein latent membrane protein 1 (LMP1), through its high-avidity binding of TRAF3, can sequester TRAF3 away from regulating other pro-survival pathways in the cell, producing a TRAF3-deficient phenotype in mouse and human DLBCL cell lines11. The gene discussed is TRAF3; the disease is diffuse large B-cell lymphoma.