To gain insight into how G3BP1 regulates α-synuclein aggregation in PD patients, we examined the expression of G3BP1 and other aggregation-associated proteins in the brain tissue (amygdala) of PD patients and non-PD individuals after fractionating the brain lysates into detergent-soluble and detergent-insoluble fractions (Fig. 8a, Table 1). The gene discussed is G3BP1; the disease is Parkinson disease.