However, focal adhesion-associated genes (CAV3, ERBB2, ITGB4, ACTN1, MYLK2, FLNA, IGF1R, LAMC3, ITGA8, ILK, ITGA7, COL6A3, PDGFRA, PDGFRB, PIK3CA, LAMC2, RELN, ITGA2B) played important roles in the long-term PMS HNSCC only group (P = 0.003, FE = 2.20) (Table S7). The gene discussed is RELN; the disease is head and neck squamous cell carcinoma.