VEGFA and malignant colon neoplasm: For colon cancer, conventional targeted therapies include epithelial growth factor receptor (EGFR) inhibitors (cetuximab and panitumumab)6,7, which slow down cancer growth, or vascular endothelial growth factor (VEGF) inhibitors (bevacizumab, ramucirumab, and Ziv-aflibercept)6,8, which suppress the angiogenesis process.