ZYX and malignant colon neoplasm: Indeed, Kim et al. verified zyxin as a marker candidate for non-small-cell lung cancer in their study70, however, the Western blot analysis of zyxin protein level found in our colon cancer cells HCT-116 was comparable to that of A549- a non-small-cell lung cancer model suggesting zyxin might act as a generic cancer therapeutic target.