IFNG and cancer: Unlike these researches that focused on the interaction of immunity and cancer cells, the present study unveiled a unique mechanism that IFN-γ promotes the apoptosis of cancer cell dependent on RNase L. The IFN-γ application promotes the homodimer formation of RNase L. Activated RNase L may further catalyze the subunits of ribosome and produces segments of rRNA, which, like a damage signal, initiate mitochondrial apoptosis.