Furthermore, pro-metastatic CD151 tetraspanin binds to TM4SF5 to display a synergistic pro-metastatic role on the cell surface; however, TM4SF5 binds anti-metastatic CD63 and sequesters it from the membrane surface into lysosomes to negate its tumor-suppressive roles14. The gene discussed is TM4SF5; the disease is neoplasm.