CCR2 and colorectal carcinoma: To investigate the molecular mechanisms responsible for regorafenib tolerance in CRC cells, we used a PCR array to profile differentially expressed signal transduction-related genes in two groups of cells (HCT116-regR/sh-NC vs. HCT116-regR/sh-CCR2 cells, HCT116/EV vs. HCT116/CCR2).