To further elucidate the molecular mechanisms of regorafenib tolerance in CRC cells, we performed a signal transduction RT2 Profiler PCR Array to profile differentially expressed genes between each group (HCT116-regR/sh-NC vs. HCT116-regR/sh-CCR2 cells, HCT116/EV vs. HCT116/CCR2). Here, EXTL3 is linked to colorectal carcinoma.