Among the 33 genes, MAOA, SAA1, ADARB1, FBN2, OMD, OGR1, NRG, UHRF1, CIDEC, DDIT4, LEPR, FOXO1, IFITM1, and HAS2 have been reported to be involved in osteogenic differentiation, osteoporosis and bone homeostasis30–42, which further validated the reliability of this dataset. Here, DDIT4 is linked to osteoporosis.