Among the 33 genes, MAOA, SAA1, ADARB1, FBN2, OMD, OGR1, NRG, UHRF1, CIDEC, DDIT4, LEPR, FOXO1, IFITM1, and HAS2 have been reported to be involved in osteogenic differentiation, osteoporosis and bone homeostasis30–42, which further validated the reliability of this dataset. The gene discussed is GPR68; the disease is osteoporosis.