MYC and malignant colon neoplasm: Both Ramos lymphoma cells with a Myc translocation and HCT116 colon cancer cells in which Myc is stabilized show sensitivity to Omomyc in a 72-h cell proliferation assay (50% inhibitory concentration [IC50] of ∼400 nM for Ramos cells and IC50 of 2 to 3 μM for HCT116 cells) (Fig. 1C).