As to circular RNA, exosomes released from gastric cancer cells deliver ciRS-133 (circular RNA sponge for miRNA-133) to pre-adipocytes, modulating the differentiation of pre-adipocytes to brown-like adipocytes through activating PR domain containing 16 (PRDM16) and inhibiting miRNA-133, which upregulates the expression of UCP1 [120]. This evidence concerns the gene PRDM16 and gastric cancer.