VEGF is highly upregulated in the breast tumor microenvironment, and VEGF/VEGFR activates oncogenic signaling pathways, including the MAPK pathway and the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, triggering the proliferation, survival, migration, and angiogenesis of breast cancer cells [43]. This evidence concerns the gene AKT1 and breast cancer.