HAVCR2 and hepatocellular carcinoma: In addition, KCs-derived galectin-9, the natural ligand for the T cell immunoglobulin domain and mucin domain protein 3 (Tim-3), leads to expansion of CD4+ CD25+ FoxP3+ Tregs, contraction of CD4+ effector T cells, and apoptosis of CTLs in HCC [91].