We found that rs1476679 interacted with a region within approximately 6 kb of the TSS of the NYAP1 (neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1) gene (Additional file 3: Figure S3B), which showed a strong eQTL effect with rs1476679 (p-value = 1.16 × 10− 11 in adipose subcutaneous tissues in the GTEx database) and was significantly upregulated in the AD hippocampus (FDR = 1.35 × 10− 4) although not in the entorhinal cortex (FDR = 0.294) (Additional file 3: Figure S3C). The gene discussed is NYAP1; the disease is Alzheimer disease.