Switching from GD2- to CD171-specific CAR-T cells increased tumor cell lyses by 30% from day 3 to day 6 while a sequential treatment with GD2-specfifc CAR-T cells showed an increase of tumor lysis of only 19% indicating a benefit for administration of sequential CAR-T cell therapy targeting different antigens. The gene discussed is L1CAM; the disease is neoplasm.