Our immunohistochemical staining revealed that LETM1 expression is positively associated with the cell cycle regulatory genes and PI3K/Akt signaling genes, such as cyclin D1 (p = 0.003), p27 (p = 0.001), pPI3K (p85) (p = 0.025), and pAkt-Thr308 (p = 0.004) expression in NSCLC tissues (Additional file 3: Table S2) (Pearson’s χ2 test). Here, CCND1 is linked to non-small cell lung carcinoma.