The immunohistochemical study revealed that LETM1 was primarily and abundantly expressed in the lung tissues of fetus (Fig. 1a, b) and in NSCLC tissues (60.0%, 45/75) (Fig. 1c-e), and rarely detectable in adjacent normal lung pulmonary alveoli (0%, 0/20) (Fig. 1f) (p < 0.001) (Pearson’s χ2 test). Here, LETM1 is linked to non-small cell lung carcinoma.