NK cells exert its function on pathogens, tumor cells, stressed hepatocytes, and HSCs via the production of cytokines (IFN-γ, TNF-α, IL-10, IL-12, IL-22, etc.)and cytotoxic molecules (granzyme B, Perforin, etc.)both in direct or indirect fashion [26]. The gene discussed is IFNG; the disease is neoplasm.