M2 TAMs can produce growth factors and cytokines such as CCL2, CXCL12, CXCR4, TGFβ, VEGF, PDGF, COX-2 and metalloproteinases that determine immunesuppression and stimulate local tumor growth as well as the metastatic process [42–44]. This evidence concerns the gene TGFB1 and neoplasm.