In the case of GnRH-I-[D-Lys6] or GnRH-II-[D-Lys6] with oxime-linked Dau, only a slight apoptotic activity could be determined on MCF-7 breast carcinoma cell line [12], while zoptarelin doxorubicin was proven to be more effective in inducing apoptosis in ovarian and endometrial carcinoma cell lines compared with the free drug [35]. The gene discussed is GNRH1; the disease is breast carcinoma.