This conjugate could elevate the members of TNF and TNFR superfamilies (e.g., TNF receptor-associated factor 3 (TRAF3) and TNF receptor superfamily (TNFRSF)10B, 20, 25), the FASL/FAS pathway and different caspases (e.g., CASP5, 8 and 10) in PANC-1 pancreatic adenocarcinoma cells [36]. Here, TRAF3 is linked to pancreatic adenocarcinoma.