It suggests that the hsa-mir-21-5p to COL5A2/OLR1, hsa-mir-135b-5p/hsa-mir-495-3p/hsa-mir-409-3p to COL5A2 and hsa-mir-224-5p/hsa-mir-21-3p/hsa-mir-135b-5p/hsa-mir-495-3p to EDNRA pathways may play substantial roles in regulation of the tumor immune microenvironment in colon cancer. This evidence concerns the gene COL5A2 and colonic neoplasm.