HMGCR and hepatocellular carcinoma: Human miR-548p could not only significantly reduce apolipoprotein B (apoB) secretion in hepatoma cells and primary hepatocytes by interacting with apoB mRNA, but also significantly repress lipid synthesis in hepatoma cells by reducing 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) and long-chain acyl-CoA synthetase 4 (ACSL4), two enzymes related to cholesterol and FA synthesis [23].