Increased miR-34a expression, which was paralleled to the increased TG accumulation, was detected in patients with nonalcoholic steatohepatitis and mice fed a high-fat diet as a result of inhibited hepatocyte nuclear factor 4 alpha (HNF4α) expression in both human and mouse hepatocytes [28]. This evidence concerns the gene HNF4A and metabolic dysfunction-associated steatohepatitis.