Notably, the treatment of PC3 and DU145 cells with the pan-PI3K and AKT inhibitors, GDC0941 and MK2206, significantly reduced the population of SORE6+ cells (Figure 5B–D), indicating that the upregulated PI3K/AKT pathway is critical for maintaining the SOX2/OCT4-overexpressing CSC population in PCa. Here, SOX2 is linked to posterior cortical atrophy.