Having identified HDACs 1, 2, and 6 as relevant targets in the synergistic effects of Mocetinostat and LMK-235 in PDAC cells, we tested the effects of HDAC1, 2, and 6 knockdown on the cytotoxicity of gemcitabine, which continues to be a mainstay in the treatment of pancreatic cancer [8,10]. Here, HDAC1 is linked to pancreatic neoplasm.