For example, very elegant work by Jill Dembowski and Neal DeLuca using EdU-labeled viral genomes followed by click-chemistry demonstrated an association of several DDR proteins including 53BP1, PARP1, PARP14, MRE11A, and Ku70(XRCC6) with HSV-1 DNA at early time points post infection [77]. The gene discussed is XRCC6; the disease is infection.