Furthermore, we demonstrated that the EVs secreted by colon cancer are enriched with miR-92a-3p and promote angiogenesis, as indicated by increased proliferation, motility, and tube formation in human umbilical vein endothelial cells (HUVECs) through the inhibition of Dickkopf-3 (Dkk-3) expression [4]. This evidence concerns the gene DKK3 and colonic neoplasm.