Therefore, it is possible that TGF-β, lymph angiogenesis and/or Vangl2 could be involved in the development of renal fibrosis and inflammation, and thus it could be a key factor in the irreversibility of kidney damage; consequently, additional studies are required to address and demonstrate the involvement of these factors in the reversibility/irreversibility of renal damage, independent of the initial stimulus. The gene discussed is VANGL2; the disease is Nephropathy.