On the other hand, the use of Fasudil, a selective ROCK inhibitor, has attracted great interest, as a potential tool in the prevention of kidney damage, in a wide variety of animal models including acute renal failure induced by ischemia-reperfusion, unilateral ureteral obstruction, hypertensive glomerulosclerosis, and renal failure induced by AngII [22]. The gene discussed is AGT; the disease is acute kidney injury.