ERBB2 and invasive ductal breast carcinoma: Proteomic analysis of invasive ductal carcinoma of the breast with luminal B human epidermal growth factor receptor 2-positive (HER2-positive LB) and HER2-enriched (HE) subtypes have shown that Prdx3 with an upregulated expression of luminal B HER2 can serve as a promising bio-signature for LB subtype and it can also serve as potential biomarker for the diagnosis of early- and late-stage disease [163].