While its activation is rapid and transient in normal cells, STAT3 was found constitutively activated as pY705-STAT3 in tumor cells, promoting an altered synthesis of key proteins responsible for the onset and progression of carcinogenesis (BIRC5 and MCL1, anti-apoptotic proteins; P21 and c-MYC, cell cycle regulators; VEGF, angiogenic factor) [6]. The gene discussed is STAT3; the disease is neoplasm.