FAT1 and tuberculosis: Transgenic mice enriched ω3-PUFAs by introducing the Caenorhabditis elegans fat-1 gene encoding an ω3-fatty acid desaturase (Fat-1 transgenic mice), which are able to produce ω3-PUFAs from ω6-PUFAs [4], are protected from inflammation-associated diseases [5,6,7], while Fat-1 transgenic mice and macrophages exhibited impaired host resistance to tuberculosis with enhanced bacterial loads and reduced inflammatory responses [8].