In Toxoplasma infection, lipoxin A4, a 5-lipoxygenase-derived eicosanoid mediator derived from the ω6-PUFA arachidonic acid, induces increased tissue cyst burden and reduces lethality associated with encephalitis, which is closely associated with the attenuation of interleukin 12 (IL-12) and interferon gamma (IFN-γ) generation [17]. This evidence concerns the gene IFNG and cyst.