In this study, two brain cell lines, namely tumour glioblastoma (A172) and differentiated neuroblastoma (d- SH-SY5Y) neuron-like cells, were scrutinised after incubation with hybrid nanoassemblies made of gold nanoparticles functionalised with angiogenin protein or with two different angiogenin-mimicking peptides (Ang60–68 and its cysteine derivative at the C-terminus, Ang60–68Cys) containing the ANG residues from 60 to 68, which is the the exposed protein loop region that is part of a cell-surface receptor binding site [56]. This evidence concerns the gene ANG and neuroblastoma.