At a molecular level, another mechanism by which obesogens could lead to weight gain or obesity is through the activation of nuclear transcription factors, such as the peroxisome proliferator-activated receptors alpha, delta, and gamma (PPARα, PPAR-δ, and PPAR-γ) and steroid hormone receptors, that regulate adipocyte proliferation and differentiation and lipid metabolism, thereby influencing body composition. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.